S\u1ef1 sinh h\u1ecdc c\u1ee7a t\u00ecnh tr\u1ea1ng ki\u1ec7t s\u1ee9c v\u00e0 nh\u1eefng g\u00ec m\u00e0 nghi\u00ean c\u1ee9u v\u1ec1 tu\u1ed5i th\u1ecd n\u00f3i v\u1ec1 m\u1ed9t trong nh\u1eefng ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u nh\u1ea5t trong l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u tu\u1ed5i th\u1ecd.<\/p>\n

Qu\u1ea3n l\u00fd m\u1ed9t c\u00f4ng ty \u1edf quy m\u00f4 l\u1edbn l\u00e0 t\u1ed1n k\u00e9m v\u1ec1 m\u1eb7t sinh l\u00fd. C\u00e1c cu\u1ed9c g\u1ecdi l\u00fac 5 gi\u1edd s\u00e1ng, c\u00e1c phi\u00ean h\u1ecdp li\u00ean t\u1ee5c v\u00e0 vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i tr\u1ea1ng th\u00e1i li\u00ean t\u1ee5c kh\u00f4ng ph\u1ea3i l\u00e0 c\u0103ng th\u1eb3ng h\u00ecnh th\u1ee9c. Ch\u00fang t\u1ea1o ra m\u1ed9t t\u1ea3i tr\u1ecdng sinh l\u00fd \u0111o \u0111\u01b0\u1ee3c. Cortisol lu\u00f4n \u1edf m\u1ee9c cao. Gi\u1ea5c ng\u1ee7 b\u1ecb ph\u00e2n m\u1ea3nh. Hi\u1ec7u su\u1ea5t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u0103ng l\u01b0\u1ee3ng (mitochondria) gi\u1ea3m xu\u1ed1ng. V\u00e0 s\u1ef1 s\u1eafc b\u00e9n tr\u00ed tu\u1ec7 m\u00e0 b\u1ea1n \u0111\u00e3 x\u00e2y d\u1ef1ng c\u00f4ng ty b\u1eaft \u0111\u1ea7u c\u1ea3m th\u1ea5y nh\u01b0 ngu\u1ed3n t\u00e0i nguy\u00ean m\u00e0 b\u1ea1n \u0111ang s\u1eed d\u1ee5ng nhanh h\u01a1n kh\u1ea3 n\u0103ng t\u00e1i t\u1ea1o ch\u00fang.<\/p>\n

H\u01a1n m\u1ed9t n\u1eeda s\u1ed1 gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh \u0111ang xem x\u00e9t nh\u1eefng y\u1ebfu t\u1ed1 b\u00ean d\u01b0\u1edbi m\u1ee9c n\u0103ng l\u01b0\u1ee3ng v\u00e0 v\u1ec7 sinh gi\u1ea5c ng\u1ee7. H\u1ecd \u0111ang t\u00ecm ki\u1ebfm c\u00e1c ph\u01b0\u01a1ng ph\u00e1p c\u1ea3i thi\u1ec7n hi\u1ec7u su\u1ea5t l\u00e0m vi\u1ec7c th\u00f4ng qua s\u1ef1 hi\u1ec3u bi\u1ebft v\u1ec1 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o. V\u00e0 m\u1ed9t ph\u00e2n t\u1eed duy nh\u1ea5t \u0111\u00e3 n\u1ed5i l\u00ean \u1edf giao \u0111i\u1ec3m gi\u1eefa qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t, ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c v\u00e0 l\u00e3o h\u00f3a sinh h\u1ecdc: NAD+.<\/p>\n

NAD+: Th\u1ef1c ch\u1ea5t n\u00f3 l\u00e0m g\u00ec?<\/h2>\n
NAD l\u00e0 kh\u00f4ng ph\u1ea3i m\u1ed9t xu h\u01b0\u1edbng ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe. N\u00f3 l\u00e0 m\u1ed9t \u0111\u1ed3ng ph\u00e2n hi\u1ec7n di\u1ec7n trong m\u1ecdi t\u1ebf b\u00e0o s\u1ed1ng, tham gia v\u00e0o h\u01a1n 500 ph\u1ea3n \u1ee9ng ph\u1ee5 thu\u1ed9c enzym. \u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi qu\u1ea3n l\u00fd mu\u1ed1n hi\u1ec3u t\u1ea1i sao n\u00f3 quan tr\u1ecdng, c\u00e1c c\u01a1 ch\u1ebf li\u00ean quan \u0111\u1ebfn ba h\u1ec7 th\u1ed1ng:<\/p>\n
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S\u1ea3n xu\u1ea5t n\u0103ng l\u01b0\u1ee3ng.<\/strong> NAD+ l\u00e0 ch\u1ea5t mang electron quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh phosphoryl h\u00f3a oxy h\u00f3a, qu\u00e1 tr\u00ecnh m\u00e0 c\u00e1c mitocondria s\u1eed d\u1ee5ng \u0111\u1ec3 chuy\u1ec3n \u0111\u1ed5i th\u1ee9c \u0103n th\u00e0nh ATP. Khi thi\u1ebfu \u0111\u1ee7 NAD+, qu\u00e1 tr\u00ecnh n\u00e0y tr\u1edf n\u00ean k\u00e9m hi\u1ec7u qu\u1ea3. C\u00e1c t\u1ebf b\u00e0o nh\u1ea1y c\u1ea3m nh\u1ea5t v\u1edbi \u0111i\u1ec1u n\u00e0y l\u00e0 neuron v\u00e0 m\u00f4 c\u01a1, ch\u00ednh nh\u1eefng t\u1ebf b\u00e0o ch\u1ecbu t\u1ea3i tr\u1ecdng c\u1ee7a c\u00f4ng vi\u1ec7c tr\u00ed tu\u1ec7 cao, s\u1ea3n xu\u1ea5t cao.<\/li>\n
Ho\u1ea1t h\u00f3a Sirtuin. Sirtuins (SIRT1 \u0111\u1ebfn SIRT7) l\u00e0 c\u00e1c enzyme ph\u1ee5 thu\u1ed9c v\u00e0o NAD+ \u0111i\u1ec1u ch\u1ec9nh bi\u1ec3u hi\u1ec7n gen, sinh t\u1ed5ng h\u1ee3p m\u00e0ng mito v\u00e0 t\u00edn hi\u1ec7u vi\u00eam. Khi NAD+ c\u1ea1n ki\u1ec7t do l\u00e3o h\u00f3a, c\u0103ng th\u1eb3ng m\u00e3n t\u00ednh ho\u1eb7c ph\u1ee5c h\u1ed3i k\u00e9m, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a sirtuin gi\u1ea3m v\u00e0 h\u1ec7 th\u1ed1ng m\u00e0 ch\u00fang \u0111i\u1ec1u ch\u1ec9nh b\u1eaft \u0111\u1ea7u b\u1ecb l\u1ec7ch.<\/li>\n
DNA s\u1eeda ch\u1eefa. Enzyme PARP ch\u1ecbu tr\u00e1ch nhi\u1ec7m s\u1eeda ch\u1eefa \u0111\u1ee9t g\u00e3y chu\u1ed7i DNA ti\u00eau th\u1ee5 NAD+ l\u00e0m ngu\u1ed3n n\u0103ng l\u01b0\u1ee3ng. M\u00f4i tr\u01b0\u1eddng c\u0103ng th\u1eb3ng cao l\u00e0m t\u0103ng t\u00e1c h\u1ea1i oxy h\u00f3a, t\u0103ng nhu c\u1ea7u c\u1ee7a PARP. Khi nhu c\u1ea7u \u0111\u00f3 kh\u00f4ng \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng, kh\u1ea3 n\u0103ng s\u1eeda ch\u1eefa gi\u1ea3m sau khi t\u00edch t\u1ee5.<\/li>\n<\/ul>\n
S\u1ef1 s\u1ee5t gi\u1ea3m theo \u0111\u01b0\u1eddng cong m\u00e0 c\u00e1c gi\u00e1m \u0111\u1ed1c n\u00ean bi\u1ebft<\/h2>\n
C\u00e1 nh\u00e2n c\u00f3 m\u1ee9c \u0111\u1ed9 NAD+ gi\u1ea3m kho\u1ea3ng 50% t\u1eeb tu\u1ed5i thanh ni\u00ean \u0111\u1ebfn gi\u1eefa tu\u1ed5i trung ni\u00ean. nghi\u00ean c\u1ee9u Gomes et al. \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Cell (2013) \u0111\u00e3 ghi nh\u1eadn s\u1ef1 s\u1ee5t gi\u1ea3m n\u00e0y \u1edf m\u00f4 c\u01a1 v\u00e0 cho th\u1ea5y n\u00f3 g\u00e2y ra r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o qua t\u00edn hi\u1ec7u SIRT1\/HIF-1alpha thay \u0111\u1ed5i. C\u0169ng ch\u00ednh nh\u1edd nghi\u00ean c\u1ee9u n\u00e0y, c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1eeb MIT, Harvard v\u00e0 \u0110\u1ea1i h\u1ecdc Washington \u0111\u00e3 ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u trong su\u1ed1t m\u1ed9t th\u1eadp k\u1ef7.<\/p>\n
\u0110\u1ed1i v\u1edbi c\u00e1c gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh trong \u0111\u1ed9 tu\u1ed5i 40 v\u00e0 50, \u00fd ngh\u0129a l\u00e0 r\u00f5 r\u00e0ng. Y\u00eau c\u1ea7u v\u1ec1 nh\u1eadn th\u1ee9c c\u1ee7a h\u1ecd cao nh\u1ea5t ch\u00ednh t\u1ea1i th\u1eddi \u0111i\u1ec3m n\u00e0y khi h\u1ec7 th\u1ed1ng t\u1ebf b\u00e0o h\u1ed7 tr\u1ee3 nh\u1eadn th\u1ee9c \u0111ang ho\u1ea1t \u0111\u1ed9ng v\u1edbi \u00edt NAD+ h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi m\u1ed9t th\u1eadp k\u1ef7 tr\u01b0\u1edbc. K\u00fd sinh tr\u00f9ng gi\u1eefa nhu c\u1ea7u v\u00e0 cung c\u1ea5p t\u1ebf b\u00e0o kh\u00f4ng ph\u1ea3i l\u00e0 gi\u1ea3 thuy\u1ebft. \u0110\u00f3 l\u00e0 t\u00e0i li\u1ec7u \u0111\u01b0\u1ee3c ghi ch\u00e9p.<\/p>\n
C\u0103ng th\u1eb3ng nh\u01b0 m\u1ed9t ch\u1ea5t x\u00fac t\u00e1c<\/h2>\n
C\u0103ng th\u1eb3ng m\u00e3n t\u00ednh l\u00e0m tr\u1ea7m tr\u1ecdng th\u00eam s\u1ef1 suy gi\u1ea3m t\u1ef1 nhi\u00ean. C\u0103ng th\u1eb3ng k\u00e9o d\u00e0i khi\u1ebfn cortisol t\u0103ng cao, k\u00edch ho\u1ea1t enzym CD38, m\u1ed9t trong nh\u1eefng ng\u01b0\u1eddi ti\u00eau th\u1ee5 NAD+ ch\u00ednh, ph\u00e1 h\u1ee7y n\u00f3 th\u00f4ng qua chu\u1ed7i ph\u1ea3n \u1ee9ng vi\u00eam. \u0110i\u1ec1u n\u00e0y t\u1ea1o ra m\u1ed9t chu k\u1ef3 c\u1ea1n ki\u1ec7t \u0111\u01b0\u1ee3c \u0111\u1ea9y nhanh l\u00ean tr\u00ean \u0111\u01b0\u1eddng cong l\u00e3o h\u00f3a b\u00ecnh th\u01b0\u1eddng.<\/p>\n
<\/figure>\n
C\u0103ng th\u1eb3ng v\u00e0 gi\u00e1n \u0111o\u1ea1n gi\u1ea5c ng\u1ee7 th\u00eam m\u1ed9t l\u1edbp ph\u1ee9c t\u1ea1p v\u00e0o v\u1ea5n \u0111\u1ec1 n\u00e0y. Enzyme NAMPT, b\u01b0\u1edbc gi\u1edbi h\u1ea1n trong qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p NAD+, tu\u00e2n theo nh\u1ecbp \u0111i\u1ec7u c\u1ee7a chu k\u1ef3 ng\u00e0y – \u0111\u00eam. Khi b\u1ecb gi\u00e1n \u0111o\u1ea1n, c\u00e1c m\u00f4 h\u00ecnh ng\u1ee7 s\u1ebd l\u00e0m ph\u1eb3ng nh\u1ecbp \u0111i\u1ec7u n\u00e0y v\u00e0 gi\u1ea3m th\u1eddi gian t\u1ed5ng h\u1ee3p ban \u0111\u00eam m\u00e0 c\u01a1 th\u1ec3 s\u1eed d\u1ee5ng cho s\u1eeda ch\u1eefa t\u1ebf b\u00e0o. M\u1ed9t gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh c\u00f3 m\u1ee9c \u0111\u1ed9 c\u0103ng th\u1eb3ng cao \u1edf tu\u1ed5i 40 c\u00f3 th\u1ec3 \u0111ang c\u00f3 n\u1ed3ng \u0111\u1ed9 NAD+ th\u1ea5p h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi tu\u1ed5i c\u1ee7a h\u1ecd ho\u1eb7c \u0111\u1ed3ng nghi\u1ec7p c\u00f3 gi\u1ea5c ng\u1ee7 t\u1ed1t h\u01a1n.<\/p>\n
N\u1ed9i dung nghi\u00ean c\u1ee9u c\u1ed9ng \u0111\u1ed3ng<\/h2>\n
C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi v\u1ec1 vi\u1ec7c b\u1ed5 sung NAD+ v\u1eabn c\u00f2n l\u00e0 m\u1ed9t l\u0129nh v\u1ef1c t\u01b0\u01a1ng \u0111\u1ed1i non tr\u1ebb. C\u00e1c b\u1eb1ng ch\u1ee9ng ti\u1ec1n l\u00e2m s\u00e0ng t\u1eeb m\u00f4 h\u00ecnh t\u1ebf b\u00e0o, nghi\u00ean c\u1ee9u l\u00e3o h\u00f3a \u0111\u1ed9ng v\u1eadt v\u00e0 c\u00e1c ph\u00e9p \u0111o c\u1ea5p t\u1ed5 ch\u1ee9c \u0111\u00e3 cho th\u1ea5y s\u1ef1 nh\u1ea5t qu\u00e1n c\u01a1 ch\u1ebf sinh l\u00fd, nh\u01b0ng \u0111i\u1ec1u n\u00e0y v\u1eabn c\u00f2n l\u00e0 m\u1ed9t l\u0129nh v\u1ef1c \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u thay v\u00ec tr\u1edf th\u00e0nh y h\u1ecdc \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c l\u1eadp.<\/p>\n
C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang xem x\u00e9t t\u00e1c \u0111\u1ed9ng c\u1ee7a vi\u1ec7c b\u1ed5 sung NAD+ \u0111\u1ed1i v\u1edbi hi\u1ec7u su\u1ea5t nh\u1eadn th\u1ee9c \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i, c\u00e1c d\u1ea5u \u1ea5n ch\u1ee9c n\u0103ng m\u00e0ng l\u01b0\u1edbi trong m\u00f4 h\u00ecnh b\u1ec7nh l\u00fd chuy\u1ec3n h\u00f3a, c\u00e1c ch\u1ec9 s\u1ed1 sinh v\u1eadt vi\u00eam trong nh\u00f3m l\u00e3o h\u00f3a v\u00e0 t\u1ef7 l\u1ec7 NAD+\/NADH nh\u01b0 d\u1ea5u hi\u1ec7u d\u1ef1 \u0111o\u00e1n s\u1ee9c kh\u1ecfe t\u1ebf b\u00e0o.<\/p>\n
C\u00e1c nh\u00e0 qu\u1ea3n l\u00fd \u0111ang x\u00e2y d\u1ef1ng m\u1ed9t quy tr\u00ecnh sinh h\u1ecdc c\u00e1 nh\u00e2n d\u1ef1a tr\u00ean nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 th\u1ec3 nh\u1eadn \u0111\u01b0\u1ee3c c\u00e1c h\u1ee3p ch\u1ea5t nghi\u00ean c\u1ee9u d\u01b0\u1ee3c ph\u1ea9m ch\u1ea5t l\u01b0\u1ee3ng cao t\u1eeb Spartan Peptides v\u1edbi ch\u1ee9ng ch\u1ec9 tinh khi\u1ebft HPLC x\u00e1c minh b\u1edfi b\u00ean th\u1ee9 ba v\u00e0 t\u00f3m t\u1eaft nghi\u00ean c\u1ee9u c\u1ee5 th\u1ec3 cho t\u1eebng h\u1ee3p ch\u1ea5t. Nh\u1eefng ng\u01b0\u1eddi s\u1eb5n s\u00e0ng t\u00edch h\u1ee3p n\u00f3 v\u00e0o quy tr\u00ecnh c\u1ee7a m\u00ecnh c\u00f3 th\u1ec3 mua NAD+ v\u1edbi s\u1ef1 minh b\u1ea1ch \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 ti\u00eau chu\u1ea9n ngu\u1ed3n g\u1ed1c, gi\u1ea5y ch\u1ee9ng nh\u1eadn tinh khi\u1ebft v\u00e0 c\u00e1c tham chi\u1ebfu c\u01a1 ch\u1ebf, lo\u1ea1i th\u00f4ng tin quan tr\u1ecdng khi \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh v\u1ec1 nh\u1eefng g\u00ec s\u1ebd \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o quy tr\u00ecnh c\u1ee7a b\u1ea1n.<\/p>\n
\u0110\u1eb7t NAD+ v\u00e0o khung n\u0103ng l\u01b0\u1ee3ng cho ng\u01b0\u1eddi l\u00e3nh \u0111\u1ea1o<\/h2>\n
Nghi\u00ean c\u1ee9u v\u1ec1 NAD+ kh\u00f4ng t\u1ed3n t\u1ea1i m\u1ed9t m\u00ecnh. C\u00e1c gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh ti\u1ebfp c\u1eadn n\u00f3 theo c\u00e1ch h\u1ec7 th\u1ed1ng v\u00e0 k\u1ebft h\u1ee3p v\u1edbi c\u00e1c bi\u1ebfn s\u1ed1 c\u01a1 b\u1ea3n: theo d\u00f5i ki\u1ebfn tr\u00fac gi\u1ea5c ng\u1ee7, t\u1eadp luy\u1ec7n s\u1ee9c m\u1ea1nh (t\u1ef1 \u0111\u1ed9ng t\u0103ng c\u01b0\u1eddng ho\u1ea1t h\u00f3a NAMPT), \u0111\u1ed9 \u0111\u1ea7y \u0111\u1ee7 protein trong ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng v\u00e0 b\u1ea3ng ch\u1ec9 s\u1ed1 sinh h\u1ecdc th\u01b0\u1eddng xuy\u00ean bao g\u1ed3m c\u00e1c d\u1ea5u hi\u1ec7u vi\u00eam v\u00e0 chuy\u1ec3n h\u00f3a.<\/p>\n
NAD+ \u0111\u00f3ng g\u00f3p v\u00e0o s\u1ef1 h\u1ed7 tr\u1ee3 \u1edf c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o cho c\u00e1c h\u1ec7 th\u1ed1ng b\u1ecb \u00e1p l\u1ef1c nhi\u1ec1u nh\u1ea5t b\u1edfi c\u00f4ng vi\u1ec7c qu\u1ea3n l\u00fd: n\u0103ng su\u1ea5t t\u01b0 duy li\u00ean t\u1ee5c, ph\u1ea3n \u1ee9ng c\u0103ng th\u1eb3ng v\u00e0 ph\u1ee5c h\u1ed3i t\u1eeb gi\u00e1n \u0111o\u1ea1n ng\u1ee7. C\u01a1 ch\u1ebf n\u00e0y n\u1eb1m \u1edf ph\u00eda tr\u00ean d\u00f2ng ch\u1ea3y. N\u00f3 kh\u00f4ng t\u1ed1i \u01b0u h\u00f3a m\u1ed9t con \u0111\u01b0\u1eddng; n\u00f3 duy tr\u00ec ti\u1ec1n t\u1ec7 n\u0103ng l\u01b0\u1ee3ng h\u00e0ng ch\u1ee5c con \u0111\u01b0\u1eddng ph\u1ee5 thu\u1ed9c v\u00e0o.<\/p>\n
\u0110\u1ed1i v\u1edbi c\u00e1c gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh qu\u1ea3n l\u00fd vi\u1ec7c huy \u0111\u1ed9ng v\u1ed1n, tuy\u1ec3n d\u1ee5ng nh\u00e2n s\u1ef1, chu k\u1ef3 s\u1ea3n ph\u1ea9m v\u00e0 \u00e1p l\u1ef1c th\u1ecb tr\u01b0\u1eddng c\u00f9ng m\u1ed9t l\u00fac, c\u00e2u h\u1ecfi kh\u00f4ng ph\u1ea3i l\u00e0 nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 \u00fd ngh\u0129a g\u00ec. Thay v\u00e0o \u0111\u00f3, n\u00f3 l\u00e0 li\u1ec7u \u0111\u1ea7u t\u01b0 v\u00e0o s\u1ee9c kh\u1ecfe t\u1ebf b\u00e0o c\u00f3 t\u01b0\u01a1ng x\u1ee9ng v\u1edbi nh\u1eefng \u0111\u00f2i h\u1ecfi v\u1ec1 tr\u00ed tu\u1ec7 \u0111\u1ed1i v\u1edbi sinh h\u1ecdc ph\u1ea3i th\u1ef1c hi\u1ec7n chi\u1ebfn l\u01b0\u1ee3c hay kh\u00f4ng. Nghi\u00ean c\u1ee9u geroscience cho th\u1ea5y n\u00f3 r\u1ea5t d\u1ec5 qu\u1ea3n l\u00fd h\u01a1n nhi\u1ec1u so v\u1edbi h\u1ea7u h\u1ebft c\u00e1c gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh nh\u1eadn ra v\u00e0 r\u1ea5t c\u1ee5 th\u1ec3 h\u01a1n l\u1eddi khuy\u00ean chung h\u1ecd th\u01b0\u1eddng nh\u1eadn \u0111\u01b0\u1ee3c.<\/p>\n
XIN L\u01afU \u00dd: T\u1ea5t c\u1ea3 c\u00e1c h\u1ee3p ch\u1ea5t \u0111\u01b0\u1ee3c \u0111\u1ec1 c\u1eadp ch\u1ec9 d\u00e0nh cho m\u1ee5c \u0111\u00edch nghi\u00ean c\u1ee9u. B\u00e0i vi\u1ebft n\u00e0y kh\u00f4ng ph\u1ea3i l\u00e0 l\u1eddi khuy\u00ean y t\u1ebf.<\/p>\n<\/div>\n<\/div>\n
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Ngu\u1ed3n: Gottabemobile<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
S\u1ef1 sinh h\u1ecdc c\u1ee7a t\u00ecnh tr\u1ea1ng ki\u1ec7t s\u1ee9c v\u00e0 nh\u1eefng g\u00ec m\u00e0 nghi\u00ean c\u1ee9u v\u1ec1 tu\u1ed5i th\u1ecd n\u00f3i v\u1ec1 m\u1ed9t trong nh\u1eefng ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nhi\u1ec1u nh\u1ea5t trong l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u tu\u1ed5i th\u1ecd. Qu\u1ea3n l\u00fd m\u1ed9t c\u00f4ng ty \u1edf quy m\u00f4 l\u1edbn l\u00e0 t\u1ed1n k\u00e9m v\u1ec1 m\u1eb7t sinh l\u00fd. C\u00e1c cu\u1ed9c g\u1ecdi […]<\/p>\n","protected":false},"author":1,"featured_media":11492,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[507,16],"tags":[],"class_list":["post-11493","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe","category-tin-tuc"],"_links":{"self":[{"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/posts\/11493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/comments?post=11493"}],"version-history":[{"count":0,"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/posts\/11493\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/media\/11492"}],"wp:attachment":[{"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/media?parent=11493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/categories?post=11493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tct.vn\/blog\/wp-json\/wp\/v2\/tags?post=11493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}